Choriocarcinoma is pathologyconfirmed malignancy of the trophoblast cell of the placenta. Choriocarcinoma of the ovary is a rare and highly malignant germ cell tumor. The current study presents an extremely rare case of nongestational pure choriocarcinoma in a postmenarcheal young female and describes details of the tumor, including the clinicopathological findings. Choriocarcinoma transactions of a conference of the international union against cancer. Placental and gestational pathology edited by raymond w. Choriocarcinoma is an aggressive neoplasm arising in the body of the uterus. Untreated choriocarcinoma characteristically presents with early hematogenous metastases common metastatic sites include lung, brain, liver, kidney and bowel metastasis may be clinically solitary and may occur in unusual locations and often present with massive hemorrhage fetus is rarely involved, even in cases of widespread metastatic disease. The testis, plural testes, are important for survival of the species. Choriocarcinoma transactions of a conference of the. There may be a peripheral solid rim of greytan tumor surrounding the central hemorrhagic areas. Kaplan, in modern surgical pathology second edition, 2009.
Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology. In 1977 8, it was observed that using a combination of gross, histologic and. Reliable information about the coronavirus covid19 is available from the world health organization current situation, international travel. B, higherpower view depicts marked trophoblastic atypia. A reference guide for gross placental examination cuts across medical disciplines bringing together obstetrics and pathology for the common goal of gross placental examination. Such cases are called gestational trophoblastic neoplasm until pathology is confirmed.
We use your linkedin profile and activity data to personalize ads and to show you more relevant ads. On gross examination, a circumscribed hemorrhagic mass is observed. Choriocarcinoma is a malignant, trophoblastic cancer, usually of the placenta. Gestational choriocarcinoma is comprised of both neoplastic syncytiotrophoblast and.
This animal received 4gy whole body irradiation three years prior to. In cases where the primary tumor has regressed, the cut surface of the testis may only show a residual scar. Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells. Description choriocarcinomas are cancers that develop from germ cells, cells that ordinarily turn into sperm or eggs. Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated. After treatment with chemo, you can still get pregnant again. Early pregnancy pathology section 2 placental and gestational. Tumors of the female sex organs hydatidiform mole and. On gross examination the resected small intestine measured 14 cm in length. We report a case of a pure ovarian choriocarcinoma, likely of nongestational origin, treated by cytoreductive surgery in combination with postoperative chemotherapy. That said, the risk of developing choriocarcinoma or other trophoblastic. Epidemiology, clinical features, gross features, and histopathology have also been discussed.
Choriocarcinoma of the ovary is a rare and aggressive tumor arising from germ cells, constituting less than 5% of all ovarian malignancies in western countries. It was written for all health care professionals who grossly examine the placenta, including obstetricians, family practice physicians, pathologists, resident physicians. Grossly, choriocarcinoma is extremely hemorrhagic in both. Webpathology is a free educational resource with 10328 high quality pathology images of benign and malignant neoplasms and related entities. Choriocarcinoma is a rare, extremely malignant type of tumour arising from the trophoblast. Download citation pathology of trophoblastic disease this chapter contains the illustrative descriptions of the various gestational trophoblastic disease that include molar pregnancies. Bulky, destructive, single to multiple dark masses in uterus with extensive central hemorrhage and variable amount of. When it is associated with gestation, it is often considered part of the spectrum of gestational trophoblastic disease. Gestational trophoblastic tumors archives of pathology. Early hematogenous spread to lungs, liver and brain. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Primary choriocarcinoma of the lung is an exceedingly rare neoplasm, and, including the combined form of choriocarcinoma and another type of carcinoma,1 only approximately 20 cases have been reported. Choriocarcinoma is pathology confirmed malignancy of the trophoblast cell of the placenta.
A hydatidiform mole carries with it a 1,000 to 2,000 fold increased risk of choriocarcinoma, one of the most striking cancer risk factors identified in humans. Choriocarcinoma definition a choriocarcinoma is type of cancer germ cell containing trophoblast cells. Lack of fetalembryonic tissue, umbilical cord, yolk sac, and amnion at gross. Choriocarcinomas resemble the cells that surround an embryo in the uterus. By far the most important risk factor for gestational choriocarcinoma is the nature of the preceding pregnancy. Choriocarcinoma also occurs after complete hydatidiform mole. Commonly, symptoms or test results can indicate choriocarcinoma. Click download or read online button to get tumors of the female sex organs hydatidiform mole and choriocarcinoma book now. Primary nongestational pure choriocarcinoma arising in. Pure nongestational choriocarcinoma is a primary germ cell neoplasm that has been defined as a tumor without other germ cell elements. Gestational trophoblastic disease abbreviated gtd, also gestational trophoblastic neoplasia abbreviated gtn, includes choriocarcinoma and hydatidiform moles. Testicular choriocarcinoma gross photo showing a bisected radical orchiectomy specimen with a lobulated hemorrhagic and necrotic testicular tumor. Complete mole may progress to choriocarcinoma in 2 3% and partial mole in choriocarcinoma, though rare, has been reported in ovary, lung, liver, mediastinum and adrenal gland.
It is characterized by early hematogenous spread to the lungs. Choriocarcinoma of the testis is a soft, friable tumor with extensive areas of hemorrhage and necrosis. Primary choriocarcinoma of the lung manifesting as diffuse. The cutup of orchiectomy specimens is dealt with in orchiectomy grossing. There is no difference in pathological appearances between gestational type and nongestational pure choriocarcinoma.
Primary mediastinal choriocarcinoma is characteristically seen in young caucasian men presenting with the symptom triad of cough, gynecornastia and chest pain. We describe an unusual case of metastatic choriocarcinoma of the pancreas arising from a regressing testicular mixed germ cell tumor that clinically mimicked a primary pancreatic tumor. Identify the gross and microscopic features of goiter, hashimotos thyroiditis, follicular adenoma and carcinoma of thyroid. Numerous and frequentlyupdated resource results are available from this search. It belongs to the malignant end of the spectrum in gestational trophoblastic disease gtd. Oclcs webjunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus. This exceptionally illustrated reference is invaluable to pathology laboratories, students, pathologist assistants, and residents, as they build detailed and precise specimen descriptions, the foundation of an accurate diagnosis.
Gross pathology handbook fills a much needed niche for a reference of terms and examples in gross dissection of autopsy and surgical pathology specimens. Choriocarcinoma occurs after pregnancy in 1 in 30,000 pregnancies in the united states 33. Gross appearance of choriocarcinoma, consisting of a hemorrhagic mass involving the endomyometrium. In this volume dr hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities. Choriocarcinoma is a true malignant neoplasm of trophoblastic cells.
The reasons that normal chorionic cells undergo cancerous change, with exaggeration of their natural and potent tendency to invade the uterine muscle and break down blood vessels, are unknown. There are three ways in which an ovarian choriocarcinoma can arise. Choriocarcinoma is a rare type of tumor that happens in women during pregnancy. Choriocarcinoma is an aggressive, highly vascular tumor. A, histologic appearance of choriocarcinoma, with biphasic trophoblastic atypia, hemorrhage, and necrosis. Choriocarcinomas are malignant tumors composed of bilaminar. If the testis is biopsied, it is usually for fertility. It is also classified as a germ cell tumor and may arise in the testis or ovary. Due to the rarity of the tumor, there is a lack of information on the clinicopathologic features, diagnosis, and treatment. When it occurs in the absence of preceding gestation, it is termed nongestational choriocarcinoma these occur most often in the ovary or testis.
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